| Name | Description | Episode |
| The Omega Directive | Requires the captain of a starship to notify Starfleet command immediately on detection of an omega molecule, and authorizesthe use of any means necessary to destroy it. This directive is unknown to virtually all Starfleet personnel, and over rides the Prime Directive. | The Omega Directive |
| Canon source | Backstage source | Novel source | DITL speculation |
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